Tuberous sclerosis: case study


Tuberous sclerosis symptom, radiology, skin sign

Tuberous sclerosis complex (TSC) is a rare multisystem autosomal dominant genetic disease that causes non-cancerous tumours to grow in the brain and on other vital organs such as the kidneysheartlivereyeslungs and skin. A combination of symptoms may include seizuresintellectual disabilitydevelopmental delay, behavioural problems, skin abnormalities, lung disease, and kidney disease

Tuberus sclerosis photo
Adenoma sebaceous 
Photo courtesy:Dr. Sulaiman khan

Tuberus sclerosis photos
Shagreen patch 
Photo courtesy: Dr Sulaiman Khan

Case story 

A 5-year-old child (male) presented to me with complaints of an a.recurrent attack of convulsion for 2 years and Delayed milestones of development 

On examination 

Pt is non-cooperative

Anaemia -

Jaundice -


Thyroid gland 

Vitals within normal limit

Skin... Adenoma sebaceous Shagreen patch


EEG: Normal

CT scan of the brain: periventricular  Calcification 

Dx.. tuberous Sclerosis.

Ct scan brain: tuberous sclerosis 

Clinical Information: H/O Convulsion Delayed milestone


 Multiple subependymal dense nodular calcification is seen in both lateral ventricles

. Ventricles are not dilated. Brain parenchyma of both cerebral hemispheres is normal in attenuation to wither any focal lesion, with well grey and white matter differentiation. 

Brainstem appears unremarkable.

 Cerebellum and CP angles are normal,

» Midbne structures are not shifted. Extroventriculor CSF spaces are not widened. Sella and para-seller regions revealed no abnormality.

Orbits revealed no obnormality+ Skull bones and soft tissue around the skull are normal.

Mucosal thickening Is seen in both maxillaries. sphenoid and ethmoid sinuses.


1, Suggestive of tuberous sclerosis.

2. Moxillery sphenoid and ethmoid sinusitis (BT)

See all medical photo here 

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